The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early Stage of NSCLC

Objective: Lung cancer has a poor prognosis. Thiol groups with high antioxidant capacity are converted to disulfide bonds through biochemical reactions that neutralize different oxidant compounds. The thiol-disulfide (SH-SS) homeostasis significant effects on cell mechanisms, transcription, and apoptosis. Here we present the prognostic role of dynamic SH-SS in patients operated for NSCLC. Materials Methods: Patients operating early-stage NSCLC were prospectively analyzed. tests measured using automated spectrophotometric method. Results: This study enrolled 138 subjects, including 77 61 healthy controls. Native thiol total levels significantly lower patient group. disulfide-to-native ratio, which is an indicator oxidative stress homeostasis, also reached level statistical significance group (p<0.001). According cut-off values (305 326.3), median overall survival rate was shorter low native Conclusions: demonstrated decreased as well SS/SH ratio Impaired may contribute lung pathogenesis prognosis because enhanced stress.